In the design of tall buildings, the lateral system that resists wind and seismic loading usually dominates the structural engineering effort; therefore, optimal lateral system design is important for material efficiency. This research intends to accelerate the conventional design process for shear wall layout with an optimization system involving a ground structure program formulation, a modified evolutionary algorithm, and innovative computational techniques. Unlike existing work that focuses either exclusively on structural performance or architectural layout, this research integrates both. An efficient computational design methodology for shear wall layout in plan is introduced. The method minimizes structural weight with constraints on torsion, flexural strength, shear strength, drift, and openings and accessibility. It can be applied from the very beginning of floor plan design or after generating an architectural floor plan.